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Thomas J George Selected Research

KRN-330

8/2014Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer.

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Thomas J George Research Topics

Disease

57Neoplasms (Cancer)
10/2022 - 11/2007
16Pancreatic Neoplasms (Pancreatic Cancer)
06/2022 - 11/2007
13Colonic Neoplasms (Colon Cancer)
11/2022 - 01/2015
13Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 08/2014
12Rectal Neoplasms (Rectal Cancer)
10/2021 - 06/2010
11Adenocarcinoma
03/2022 - 12/2009
5Circulating Neoplastic Cells
03/2022 - 01/2017
5Neoplasm Metastasis (Metastasis)
01/2018 - 01/2014
3Microsatellite Instability
10/2022 - 11/2016
3Cachexia
01/2019 - 01/2017
2Residual Neoplasm
01/2022 - 12/2020
2Neutropenia
01/2021 - 08/2014
2Diarrhea
01/2021 - 06/2010
2Disease Progression
06/2017 - 08/2014
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2011 - 02/2010
2Melanoma (Melanoma, Malignant)
01/2010 - 03/2008
1Turcot syndrome
10/2022
1Peripheral Nervous System Diseases (PNS Diseases)
10/2022
1Death (Near-Death Experience)
01/2022
1Stomatitis
01/2021
1Vomiting
01/2021
1Thrombocytopenia (Thrombopenia)
01/2021
1Anemia
01/2021
1Infections
01/2021
1Nausea
01/2021
1Liver Neoplasms (Liver Cancer)
01/2021
1Hepatocellular Carcinoma (Hepatoma)
01/2021
1Leukopenia
01/2021
1Leukemia
03/2020
1Weight Gain
01/2020
1Cardiotoxicity
01/2019
1Cardiomyopathies (Cardiomyopathy)
01/2019
1Acute-Phase Reaction
01/2019
1Insulin Resistance
01/2019

Drug/Important Bio-Agent (IBA)

8Biomarkers (Surrogate Marker)IBA
03/2022 - 05/2013
7Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2022 - 10/2017
7Fluorouracil (Carac)FDA LinkGeneric
10/2022 - 08/2017
5Capecitabine (Xeloda)FDA Link
10/2022 - 06/2010
5Pharmaceutical PreparationsIBA
03/2020 - 05/2013
4Immune Checkpoint InhibitorsIBA
01/2022 - 08/2018
4Cetuximab (Erbitux)FDA Link
01/2021 - 03/2010
4GemcitabineFDA Link
01/2018 - 11/2007
3Biological ProductsIBA
01/2020 - 01/2014
3Interleukin-8 (Interleukin 8)IBA
01/2017 - 10/2015
3Monoclonal AntibodiesIBA
12/2016 - 03/2010
2Leucovorin (Folinic Acid)FDA Link
10/2022 - 01/2018
2Circulating Tumor DNAIBA
03/2022 - 01/2022
2Sodium Glutamate (Accent)IBA
11/2021 - 01/2021
2Trinitrotoluene (TNT)IBA
08/2021 - 10/2016
2pembrolizumabIBA
08/2021 - 11/2019
2AntibodiesIBA
03/2020 - 11/2016
2BuffersIBA
01/2020 - 01/2014
2Bevacizumab (Avastin)FDA Link
01/2019 - 01/2018
2Proteins (Proteins, Gene)FDA Link
01/2019 - 01/2015
2Irinotecan (Camptosar)FDA LinkGeneric
01/2018 - 08/2014
2Interleukin-6 (Interleukin 6)IBA
01/2017 - 01/2017
2ErbB Receptors (EGF Receptor)IBA
11/2016 - 03/2010
2Trastuzumab (Herceptin)FDA Link
04/2016 - 01/2015
2InterferonsIBA
12/2015 - 01/2010
1Cell-Free Nucleic AcidsIBA
03/2022
1sotorasibIBA
01/2022
1Algenpantucel-LIBA
01/2022
1Cancer VaccinesIBA
01/2022
1adagrasibIBA
01/2022
1src-Family KinasesIBA
10/2021
1Dasatinib (BMS 354825)FDA Link
10/2021
1Sorafenib (BAY 43-9006)FDA Link
01/2021
1Panitumumab (Vectibix)FDA Link
01/2021
1Tyrosine Kinase InhibitorsIBA
01/2021
1AndrogensIBA
01/2021
1Blood Glucose (Blood Sugar)IBA
01/2021
1neratinibIBA
01/2021
1trifluridine tipiracil drug combinationIBA
01/2021
1cyclopropapyrroloindoleIBA
01/2021
1DNA (Deoxyribonucleic Acid)IBA
12/2020
1Epithelial Cell Adhesion MoleculeIBA
03/2020
1Immobilized AntibodiesIBA
01/2020
1LeptinIBA
01/2020
1NivolumabIBA
11/2019
1triplex DNA (H-DNA)IBA
11/2019
1IpilimumabIBA
11/2019
1Agammaglobulinaemia Tyrosine KinaseIBA
01/2019
1erucylphosphocholineIBA
01/2019
1durvalumabIBA
01/2019
1GhrelinIBA
01/2019
1ibrutinibIBA
01/2019
1Serum AlbuminIBA
01/2019
1AntimetabolitesIBA
01/2019

Therapy/Procedure

34Therapeutics
10/2022 - 11/2007
22Drug Therapy (Chemotherapy)
10/2022 - 02/2010
11Neoadjuvant Therapy
10/2022 - 01/2015
8Radiotherapy
10/2017 - 12/2009
5Adjuvant Chemotherapy
11/2022 - 10/2017
4Immunotherapy
01/2022 - 01/2010
2Lab-On-A-Chip Devices
03/2022 - 01/2017
2Treatment Delay
01/2021 - 01/2017
2Precision Medicine
01/2018 - 01/2016
2Pancreaticoduodenectomy
01/2017 - 01/2016
1Continuity of Patient Care
06/2022
1Duration of Therapy
01/2019